D-Serine as a putative glial neurotransmitter
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چکیده
منابع مشابه
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission.
Although D amino acids are prominent in bacteria, they generally are thought not to occur in mammals. Recently, high levels of D-serine have been found in mammalian brain where it activates glutamate/N-methyl-D-aspartate receptors by interacting with the "glycine site" of the receptor. Because amino acid racemases are thought to be restricted to bacteria and insects, the origin of D-serine in m...
متن کاملNeurobiology through the looking-glass: D-serine as a new glial-derived transmitter.
D-Amino acids have been known to be present in bacteria for more than 50 years, but only recently they were identified in mammals. The occurrence of D-amino acids in mammals challenge classic concepts in biology in which only L-amino acids would be present or thought to play important roles. Recent discoveries uncovered a role of endogenous D-serine as a putative glial-derived transmitter that ...
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Svenneby. G. (1971) J . Neurochem. 18, 2201-2208 Svenneby, G. & Storm-Mathisen, J. (1983) in Glutamine, Gluramute, and GABA in rhe Cenrrul Nervous System (Hertz, L., Kvamme, E., McGeer, E. G., & Schousboe, A,, eds.), pp. 69-76, Alan R. Liss, New York Svenneby, G., Torgner, 1. Aa. & Kvamme, E. (1973) J. Neurochem. 20, 121 7-1224 Svenneby, G.. Hogstad, S., Torgner, 1. Aa. & Kvamme, E. (19860) J. ...
متن کاملD-serine signalling as a prominent determinant of neuronal-glial dialogue in the healthy and diseased brain
Rather different from their initial image as passive supportive cells of the CNS, the astrocytes are now considered as active partners at synapses, able to release a set of gliotransmitter-like substances to modulate synaptic communication within neuronal networks. Whereas glutamate and ATP were first regarded as main determinants of gliotransmission, growing evidence indicates now that the ami...
متن کاملGlial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex.
N-methyl-D-aspartate receptors (NMDARs) subserve numerous neurophysiological and neuropathological processes in the cerebral cortex. Their activation requires the binding of glutamate and also of a coagonist. Whereas glycine and D-serine (D-ser) are candidates for such a role at central synapses, the nature of the coagonist in cerebral cortex remains unknown. We first show that the glycine-bind...
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ژورنال
عنوان ژورنال: Neuron Glia Biology
سال: 2004
ISSN: 1740-925X,1741-0533
DOI: 10.1017/s1740925x05000141